HBX 28258 ( HBX28258 )

产品货号. M11801 CAS No. 1426544-54-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

HBX 28258
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

HBX 28258 is a potent, selective USP7 inhibitor with IC50 of 22.6 uM.
产品描述

HBX 28258 is a potent, selective USP7 inhibitor with IC50 of 22.6 uM, exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1; reduces HCT116 cell proliferation, induces caspase activity and PARP cleavage, and arrestes HCT116 cancer cells in G1 phase.
同义词

HBX28258
通路

Proteasome/Ubiquitin
靶点

DUB
受体

DUB
研究领域

——
适应症

——

CAS Number

1426544-54-8
分子量

436.00
分子式

C26H30ClN3O
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(C1=CC2=C(Cl)C3=C(CCCC3)N=C2C=C1)NCCCN(CC)CC4=CC=CC=C4
化学全称

2-Acridinecarboxamide, 9-chloro-N-[3-[ethyl(phenylmethyl)amino]propyl]-5,6,7,8-tetrahydro-

1. Reverdy C, et al. Chem Biol. 2012 Apr 20;19(4):467-77.

计算器

产品手册

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